De novo BK channel mutation causes epilepsy by regulating voltage-dependent, but not calcium-dependent, activation
Q. K. Wang, M. Willemsen, X. Li, S. Poschmann, Q. Chen, N. J. Oundjian, F. M. Snoeijen-Schouwenaars, E.-J. Kamsteeg
This study identifies a de novo BK channel mutation causing epilepsy by enhancing voltage-dependent activation, while not affecting calcium sensitivity.
bioRxiv · Mar 25, 2017Biophysics