Topological analysis of single-cell data reveals shared glial landscape of macular degeneration and neurodegenerative diseases
Manik Razdan Kuchroo, Marcello DiStasio, Eda Calapkulu, Maryam Ige, Le Zhang, Amar H. Sheth, Madhvi Menon, Yu Xing, Scott Gigante, Jessie Huang, Rahul M. Dhodapkar, Bastian Rieck, Guy Wolf, Smita Krishnaswamy, Brian P. Hafler
A topological machine learning approach applied to single-nucleus RNA sequencing identifies shared glial activation states in AMD, AD, and MS.
bioRxiv · Jan 19, 2021 · PreprintNeuroscience