Brian P. Hafler

This paper identifies a NGF variant that selectively biases TrkA signaling towards neurotrophic functions without triggering pain, revealing mechanisms for therapeutic targeting of the NGF-TrkA pathway.

This paper scales large language models for single-cell analysis, improving predictive and generative capabilities and enabling biological discovery through virtual screening.

A topological machine learning approach applied to single-nucleus RNA sequencing identifies shared glial activation states in AMD, AD, and MS.