Mechanistically explainable AI model for predicting synergistic cancer therapy combinations
Han Si, Sanyam Kumar, Sneh Lata, Arshad Ahmad, Saurav Kumar Ghosh, Karen Stephansen, Deepti R. Nagarkar, Eda Zhou, Brandon W. Higgs
This paper introduces an LLM-based framework that predicts synergistic cancer drug combinations using drug data and a knowledge graph, achieving an F1 score of 0.80.
Current Oncology · Sep 30, 2025Peer-reviewedCancer Biology