Gαq Mediates Clozapine Effects in Caenorhabditis elegans
Limin Hao, Yong‐Guang Tong, Kristin Harrington, Jessica L. O’Neill, Afsaneh Sheikholeslami, Xin Wang, Jonathan H. Freedman, Bruce M. Cohen, Edgar A. Buttner
This study identifies Gαq as a mediator of clozapine effects in C. elegans by showing that mutations in dopamine receptors and Gq proteins alter clozapine susceptibility and developmental outcomes.
bioRxiv · Jan 24, 2017 · PreprintGenetics