Tissue Level Profiling of SARS-CoV-2 antivirals in mice to predict their effects: comparing Remdesivir's active metabolite GS-441 524 vs. the clinically failed Hydroxychloroquine
Oliver Scherf‐Clavel, Edith Kaczmarek, Martina Kinzig, Bettina Friedl, Malte Feja, Rainer Höhl, Roland Nau, Ulrike Holzgrabe, Manuela Gernert, Franziska Richter, F. Sörgel
This study compares the tissue distribution and pharmacokinetics of GS-441 524 and hydroxychloroquine in mice to assess their potential antiviral efficacy against SARS-CoV-2.
bioRxiv · Sep 16, 2020 · PreprintSystems Biology