Within-family attenuation of polygenic risk score accuracy: Investigating the effects of principal component analysis, LD score regression, and mixed model association in the UK Biobank
Ciaran Michael Kelly, Onyedika Onuorah, Edmund Gilbert
This study evaluates how population structure adjustment methods affect polygenic risk score performance in within-family settings using UK Biobank data.
Human Genetics · Jul 4, 2026Peer-reviewedGenetic & Genomic Medicine