This study uses ancient genomes to analyze adaptive evolution in East Asia, finding pre-Neolithic selection at key loci and a link between ADH1B*48His and wheat farming.

bioRxiv · Oct 23, 2026 · PreprintEvolutionary Biology

Rapid and robust sex determination from ancient enamel proteomes using protSexInferer

Fan Bai, Zhongyou Wu, Xia Song, Qiaomei Fu

Using the share of AMELY-specific among all sex-specific amelogenin peptides (RAMELY), enamel proteomes are sexed consistently across four search engines, tolerating false-positive AMELY hits without manual checks.

Journal of genetics and genomics/Journal of Genetics and Genomics · Apr 22, 2026Peer-reviewedPaleontology✦ In-depth digest

A Refined Analysis of Neanderthal-Introgressed Sequences in Modern Humans with a Complete Reference Genome

Shen-Ao Liang, Tianxin Ren, Jiayu Zhang, Jiahui He, Xuankai Wang, Xinrui Jiang, Yuan He, Rajiv C. McCoy, Qiaomei Fu, Joshua M. Akey, Yafei Mao, Lu Chen

This study remaps Neanderthal and Denisovan genomes onto new and old references, finds improved mapping with T2T-CHM13, and identifies new introgressed sequences and population-specific archaic ancestry.

Genome biology · Feb 17, 2025Peer-reviewedEvolutionary Biology

The population history of northeastern Siberia since the Pleistocene

Martin Sikora, Владимир Викторович Питулько, Vítor C. Sousa, Morten E. Allentoft, Lasse Vinner, Simon Rasmussen, Ashot Margaryan, Peter de Barros Damgaard, Constanza de la Fuente Castro, Gabriel Renaud, Melinda A. Yang, Qiaomei Fu, Isabelle Dupanloup, Konstantinos Giampoudakis, David Nogués‐Bravo, , Eske Willerslev

This paper analyzes ancient genomes from northeastern Siberia to reveal complex population migrations and admixture events over the past 40,000 years.

Nature · Jun 5, 2019Peer-reviewedGenomics

The genetic structure of the world’s first farmers

Iosif Lazaridis, Dani Nadel, Gary Rollefson, Deborah C. Merrett, Nadin Rohland, Swapan Mallick, Daniel Fernandes, Mario Novak, Beatriz Gamarra, Kendra Sirak, Sarah Connell, Kristin Stewardson, Eadaoin Harney, Qiaomei Fu, Gloria Gonzalez-Fortes, , D.

This study analyzes ancient DNA from 44 Near Easterners to trace genetic changes from hunter-gatherers to farmers and their spread across regions.

bioRxiv · Jun 16, 2016Genetics

A Chronological Atlas of Natural Selection in the Human Genome during the Past Half-million Years

Hang Zhou, Sile Hu, Rostislav Matveev, Qianhui Yu, Jing Li, Philipp Khaitovich, Li Jin, Michael Lachmann, Mark Stoneking, Qiaomei Fu, Kun Tang

This study estimates the timing of natural selection in the human genome over the past half-million years, identifying selection events related to brain evolution and Alzheimer's disease pathways.

bioRxiv · Jun 19, 2015 · PreprintEvolutionary Biology

Massive migration from the steppe is a source for Indo-European languages in Europe

Wolfgang Haak, Iosif Lazaridis, Nick Patterson, Nadin Rohland, Swapan Mallick, Bastien Llamas, Guido Brandt, Susanne Nordenfelt, Eadaoin Harney, Kristin Stewardson, Qiaomei Fu, Alissa Mittnik, Eszter Bánffy, Christos Economou, Michael Francken, , Kurt We

The paper analyzes ancient DNA data from 69 Europeans to show that a massive migration from the steppe contributed to the genetic makeup of present-day Europeans and supports a steppe origin for some Indo-European languages.

bioRxiv · Feb 10, 2015Genetics

Ancient human genomes suggest three ancestral populations for present-day Europeans

Iosif Lazaridis, Nick Patterson, Alissa Mittnik, Gabriel Renaud, Swapan Mallick, Karola Kirsanow, Peter H. Sudmant, Joshua G. Schraiber, Sergi Castellano, Mark Lipson, Bonnie Berger, Christos Economou, Ruth Bollongino, Qiaomei Fu, Kirsten Bos, , Claudio M.

The paper analyzes ancient genomes to show present-day Europeans derive from three populations: WHG, ANE, and EEF, with EEF having Basal Eurasian ancestry.

Nature · Sep 17, 2014Peer-reviewedGenetics