Author

Ciaran Michael Kelly

Royal College of Surgeons in IrelandORCID 0009-0003-9300-7817Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Research Focus:polygenic risk· 2 Research Focus:benchmarking· 1 Approach:matrix factorization· 1 Approach:mixed model· 1

Frequent Co-Authors

Ahmad Al KhleifatiD· 1 shared Ajay Srinivasan Harikrishnan· 1 shared Alfredo IacoangeliiD· 1 shared Ammar Al‐ChalabiiD· 1 shared Edmund Gilbert· 1 shared Emrah KacariD· 1 shared Jan Herman VeldinkiD· 1 shared Onyedika Onuorah· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Ahmad Al KhleifatORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintAug 21, 2026

Evaluating the Impact of Principal Component and Mixed Model Approaches on Polygenic Risk Score Portability to Diverse Ancestries in the UK Biobank

Ajay Srinivasan Harikrishnan, Ciaran Michael Kelly

This study evaluates how principal component and mixed model approaches affect polygenic risk score portability across different ancestries in the UK Biobank.

DOI 10.64898/2026.08.17.26360388

humanGWAS summary statistics

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Genetic & Genomic MedicineHuman GeneticsPeer-reviewedJul 4, 2026

Within-family attenuation of polygenic risk score accuracy: Investigating the effects of principal component analysis, LD score regression, and mixed model association in the UK Biobank

Ciaran Michael Kelly, Onyedika Onuorah, Edmund Gilbert

This study evaluates how population structure adjustment methods affect polygenic risk score performance in within-family settings using UK Biobank data.

1 citation

humanwhole-genome sequencing

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Genetic & Genomic MedicinemedRxivPreprintMay 25, 2024

Sex-specific risk loci and modified MEF2C expression in ALS

Ross Patrick Byrne, Wouter van Rheenen, Tomás DS Gomes…·Russell Lewis McLaughlin

The paper identifies sex-specific risk loci for ALS, including MEF2C, which is upregulated in female ALS motor neurons, and an X-chromosome locus at IL1RAPL2.

4 citations

humanGWAS summary statistics

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