The selective OX1R antagonist 1-SORA-51 reduces binge-like feeding behavior in male and female mice without detectable changes in dopamine.
Ralph Dileone, Richard Trinko, Etienne Ndzie Atangana, Deven M Diaz, Avishag Ashkenazi, Ethan P. Foscue, Edward M. Kong
This study shows that the OX1R antagonist 1-SORA-51 reduces early binge-like feeding in mice without affecting dopamine levels.
bioRxiv · Apr 28, 2026 · PreprintNeuroscience