In vitro discovery and optimization of a human monoclonal antibody that neutralizes neurotoxicity and lethality of cobra snake venom
Line Ledsgaard, Andreas H. Laustsen, Urška Puš, Jack Wade, Pedro Villar, Kim Boddum, Peter Slavny, Edward W. Masters, Ana Silvia Arias, Saioa Oscoz, Daniel T. Griffiths, Alice M. Luther, Majken Lindholm, Rachael A. Leah, Marie Sofie Møller, , Aneesh Karatt-Vellatt
A recombinant human monoclonal antibody was optimized to neutralize whole cobra venom in mice, preventing lethality by targeting neurotoxins.
bioRxiv · Sep 7, 2021 · PreprintMolecular Biology