Metabolic adaptation to TCA cycle deficiency in a strictly aerobic bacterium
Changshuo Liu, Eemeli Toivanen, Suvi Santala, Jin Luo, Ville P. Santala
This study shows that adaptive evolution can restore growth in a bacterium with a disrupted TCA cycle by reorganizing central metabolism and improving redox balance.
bioRxiv · Sep 18, 2026 · PreprintBioengineering