Ville P. Santala

3D-Printable and Cytocompatible Hydrogel from Acinetobacter baylyi ADP1 Extracellular Matrix

This paper develops a 3D-printable, cytocompatible hydrogel from Acinetobacter baylyi ADP1 extracellular matrix, demonstrating its versatility for biofabrication.

Metabolic adaptation to TCA cycle deficiency in a strictly aerobic bacterium

This study shows that adaptive evolution can restore growth in a bacterium with a disrupted TCA cycle by reorganizing central metabolism and improving redox balance.

Dual-Chassis Strategy for Bridging Adaptive Evolution and Rational Design for Synthetic Biology

The paper introduces a dual chassis framework (DUET) to combine rational metabolic design with adaptive evolution, enabling robust microbial platform development.

Metabolic engineering of Acinetobacter baylyi ADP1 for efficient utilization of pentose sugars and production of glutamic acid

This paper engineers Acinetobacter baylyi ADP1 to efficiently utilize pentose sugars and produce L-glutamate, achieving high growth rates and carbon yields.

Metabolic engineering of Acinetobacter baylyi ADP1 for naringenin production

This study engineers Acinetobacter baylyi ADP1 to produce naringenin by modifying its metabolism and introducing plant-derived enzymes, achieving 66 mg/L in fed-batch cultures.

Modulating Bacterial Nanocellulose Crystallinity through Post-Transcriptional Repression in Komagataeibacter xylinus

This paper develops sRNA-based post-transcriptional repression cassettes to modulate BC crystallinity in K. xylinus, achieving gene expression reductions and structural changes in nanocellulose.

Dynamic decoupling of biomass and lipid biosynthesis by autonomously regulated switch

This paper engineers a dynamic genetic circuit in Acinetobacter baylyi ADP1 to redirect carbon flow from biomass to wax ester production, improving yield and titer by over 3-fold.