Molecular control of replication licensing speed by c-MYC
Dalia Fleifel, Abid Ali Khan, Abdalla A Alkhawaja, Arthi Adavikolanu, Sidra Qayyum, Eiman Elkoumy, Jeanette Gowen Cook
This study identifies c-MYC as a non-canonical origin licensing accelerator, showing it increases licensing speed through TRRAP/GCN5 and histone H1 eviction, particularly in heterochromatin.
bioRxiv · Oct 30, 2026 · PreprintMolecular Biology