Dalia Fleifel

Molecular control of replication licensing speed by c-MYC

This study identifies c-MYC as a non-canonical origin licensing accelerator, showing it increases licensing speed through TRRAP/GCN5 and histone H1 eviction, particularly in heterochromatin.

ELDR-Glo, a biosensor for cell age that correlates with quiescence depth

ELDR-Glo is a fluorescent biosensor that estimates relative cell age and quiescence depth, functioning in both live and fixed cells.

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination

This study identifies USP37 as a deubiquitinase that prevents premature replisome disassembly by deubiquitinating MCM7, ensuring genome stability and normal cell cycle progression.

Extrachromosomal DNA Gives Cancer a New Evolutionary Pathway

The paper shows that ecDNA allows tumors to adapt rapidly by maintaining a spectrum of gene expression levels across cells, rather than relying on clonal expansion.