Improving SBRT by re-wiring immunosuppressive neutrophils in murine pancreatic ductal adenocarcinoma
Joseph D. Murphy, Gary Hannon, Bradley N. Mills, Angela L. Hughson, Taylor Paige Uccello, Nicholas W Gavras, Jian Ye, Brian A. Belt, Maggie L. Lesch, Sarah L Eckl, Elena B. Barr, Edith M. Lord, Minsoo Kim, Haoming Qiu, David C. Linehan, Scott A. Gerber
This study investigates the role of immunosuppressive neutrophils in SBRT-treated murine PDAC and shows that re-wiring them with IL-12 improves treatment efficacy.
International Journal of Radiation Oncology*Biology*Physics · Jul 2, 2025Peer-reviewedImmunology