Author

Maggie L. Lesch

University of Rochester MedicineORCID 0000-0002-7080-2020Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Angela L. Hughson· 2 shared David C. LinehaniD· 2 shared Gary HannoniD· 2 shared Sarah L EckliD· 2 shared Scott A. GerberiD· 2 shared Bradley N. Mills· 1 shared Brian A. Belt· 1 shared Edith M. Lord· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Angela L. Hughson

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2 papers

Recent·Most cited

Local delivery of SBRT and IL-12 to Murine PDAC Tumors Modulates Hematopoiesis

Tara G Vrooman, Emily R. Quarato, Gary Hannon, Noah Salama, Maggie L. Lesch, Angela L. Hughson, Vedika S. Chandak, Nataliia Vdovichenko, Zhiming Jin, Ronald Lakony, Jian Ye, Sarah L Eckl, Sidney Lesser, Edith M. Lord, David C. Linehan, , Scott A. Gerber

This study shows that local delivery of SBRT and IL-12 to PDAC tumors in mice affects bone marrow hematopoiesis, causing both acute and long-term changes.

OncoImmunology · Jun 5, 2026Peer-reviewedImmunology

Improving SBRT by re-wiring immunosuppressive neutrophils in murine pancreatic ductal adenocarcinoma

Joseph D. Murphy, Gary Hannon, Bradley N. Mills, Angela L. Hughson, Taylor Paige Uccello, Nicholas W Gavras, Jian Ye, Brian A. Belt, Maggie L. Lesch, Sarah L Eckl, Elena B. Barr, Edith M. Lord, Minsoo Kim, Haoming Qiu, David C. Linehan, Scott A. Gerber

This study investigates the role of immunosuppressive neutrophils in SBRT-treated murine PDAC and shows that re-wiring them with IL-12 improves treatment efficacy.

International Journal of Radiation Oncology*Biology*Physics · Jul 2, 2025Peer-reviewedImmunology