Powassan Virus LB Neurovirulence and Lethality is Determined by Envelope Protein Domain III Residues
Marissa R. Lindner, Elena E. Gorbunova, Marcos Romário Matos de Souza, Grace E. Himmler, Hwan Keun Kim, Erich R. Mackow
This study identifies specific envelope protein domain III residues that determine neurovirulence and lethality of Powassan Virus lineage I, showing that mutations can attenuate the virus and elicit protective immunity.
bioRxiv · Mar 27, 2026 · PreprintMicrobiology