Proteoform-level deconvolution reveals a broader spectrum of ibrutinib off-targets
Isabelle Rose Leo, Elena Kunold, Anastasia Audrey, Marianna Tampere, Jürgen Eirich, Rozbeh Jafari
This study identifies additional proteoform targets of ibrutinib using thermal proteome profiling, revealing off-target interactions linked to immunomodulation and cellular processes.
bioRxiv · Nov 14, 2023 · PreprintMolecular Biology