A kidney specific mouse model to study the effects of in vivo induction of Yamanaka factors
Katharina Lemberg, Gijs A. C. Franken, Korbinian Maria Riedhammer, Selina Hölzel, Kirollos Yousef, Kraisoon Lomjansook, Gina S Kalkar, Caroline Maria Kolvenbach, Daniel S. Marchuk, Elena Zion, Ken Saida, Florian Buerger, Friedhelm Hildebrandt
This study investigates the effects of in vivo induction of Yamanaka factors (OKS) in a kidney-specific mouse model to enhance tissue repair after acute kidney injury, finding that while feasible, it carries risks of oncogenic transformation.
bioRxiv · Aug 30, 2025 · PreprintDevelopmental Biology