MARCKS domain phosphorylation regulates the differential interaction of Diacylglycerol Kinase ζ with Rac1, RhoA and Syntrophin
Ryan Ard, Jean-Christian Maillet, Elias Daher, Michael Phan, Radoslav Zinoviev, Robin J. Parks, Stephen H. Gee
This study shows that PKC-mediated phosphorylation of DGKζ's MARCKS domain switches DGKζ interactions from Rac1 to RhoA and Syntrophin, promoting RhoA-driven blebbing over Rac1-driven migration.
bioRxiv · Jul 8, 2020 · PreprintCell Biology