Dredd-mediated cleavage of Kenny uncouples the IKK complex from selective autophagy to enable innate immunity
Aravind K. Mohan, Anna M. Dahlström, Anna L. Aalto, Kerttu Kotala, Veera Luukkonen, Fanny Serenius, Elinda Helin, Tor Erik Rusten, Annika Meinander
The paper shows that Dredd cleaves Kenny, releasing the IKK complex from autophagosomal repression to activate NF-κB and enable antibacterial immunity.
bioRxiv · Apr 25, 2026 · PreprintMolecular Biology