Tor Erik Rusten

Dredd-mediated cleavage of Kenny uncouples the IKK complex from selective autophagy to enable innate immunity

The paper shows that Dredd cleaves Kenny, releasing the IKK complex from autophagosomal repression to activate NF-κB and enable antibacterial immunity.

Time-resolved functional genomics using deep learning reveals a global hierarchical control of autophagy

This study uses deep learning and time-resolved imaging to map the genetic network controlling autophagy dynamics, revealing a hierarchical control mechanism and new regulatory aspects.

Interclonal cooperation and suppression shape early Ras-driven tumour growth

This study identifies cooperative and suppressive interclonal interactions during early Ras-driven tumourigenesis using a Drosophila model, revealing key modifiers like SWI/SNF and cell competition regulators.

Oncogenic Ras-driven Dorsal/NF-κB signaling contributes to tumorigenesis in a Drosophila carcinoma model

This study shows that oncogenic RasV12 activates Dorsal/NF-κB signaling, promoting tumor growth and malignancy in Drosophila melanogaster tumors.

EyaHOST a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster

The paper introduces EyaHOST, a genetic system in Drosophila for studying tumor-host interactions by enabling tissue-specific manipulation of host cells and tissues.