Increased APOEϵ4 expression is associated with reactive A1 astrocytes and the difference in Alzheimer Disease risk from diverse ancestral backgrounds
Katrina Celis, Anthony J. Griswold, Parker L. Bussies, Farid Rajabli, Patrice L. Whitehead, Kara L. Hamilton‐Nelson, Gary W. Beecham, Derek Michael Dykxhoorn, Karen Nuytemans, Liyong Wang, Olivia K. Gardner, Daniel A. Dorfsman, Eileen H. Bigio, Marsel M. Mesulam, Sandra Weıntraub, , Jeffery M. Vance
The paper finds that APOEϵ4 expression is higher in European ancestry carriers and linked to A1 reactive astrocytes, potentially explaining higher AD risk in this group.
Alzheimer s & Dementia · Dec 1, 2020Peer-reviewedGenomics