Marsel M. Mesulam

The paper investigates the role of the ventral visual stream in reading, showing that only the most anterior region of the orthographic stream connects to the transmodal language network and responds to meaningful speech.

This study uses whole genome sequencing and AI to identify genetic variants associated with TDP43-Type-C neurodegeneration, finding novel links to FIG4, UBQLN2, INPP5A, and ANXA11.

This study identifies heteromeric amyloid filaments composed of ANXA11 and TDP-43 in FTLD-TDP Type C using cryo-EM, revealing a new pathological mechanism.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

The paper finds that APOEϵ4 expression is higher in European ancestry carriers and linked to A1 reactive astrocytes, potentially explaining higher AD risk in this group.

This study compares whole hippocampus and subfield biomarkers for Alzheimer’s disease detection and prediction using multimodal MRI data, finding subiculum biomarkers improve prediction accuracy.

This paper introduces SuStaIn, a machine learning method that identifies disease subtypes and their temporal progression from cross-sectional data, improving prediction of diagnostic conversion in neurodegenerative diseases.