Author

Eileen H. Bigio

Northwestern UniversityORCID 0000-0002-9554-1138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Bernardino Francesco GhettiiD· 2 shared Douglas R GalaskoiD· 2 shared Gary W. BeechamiD· 2 shared Jonathan L. HainesiD· 2 shared Kara L. Hamilton‐NelsoniD· 2 shared Lawrence S. HonigiD· 2 shared Marilyn AlbertiD· 2 shared Marla GearingiD· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Bernardino Francesco GhettiORCID

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Author profile →

3 papers

Recent·Most cited

Manifestations of genetic risk for Alzheimer's Disease in the blood: a cross-sectional multi-omic analysis in healthy adults aged 18-90+

Laura M. Heath, John C. Earls, Andrew T. Magis, Sergey A. Kornilov, Jennifer C. Lovejoy, Cory C. Funk, Noa Rappaport, Benjamin A. Logsdon, Lara M. Mangravite, Brian W. Kunkle, Eden R. Martin, Adam Christian Naj, Nilüfer Ertekin‐Taner, Todd Eliot Golde, Leroy Hood, , Jeffrey Alan Kaye

This study identifies blood-based biomarkers associated with Alzheimer's disease genetic risk variants in a large cohort of healthy adults, showing effects from early adulthood and sex-specific patterns.

Scientific Reports · Apr 12, 2022Peer-reviewedGenetics

Increased APOEϵ4 expression is associated with reactive A1 astrocytes and the difference in Alzheimer Disease risk from diverse ancestral backgrounds

Katrina Celis, Anthony J. Griswold, Parker L. Bussies, Farid Rajabli, Patrice L. Whitehead, Kara L. Hamilton‐Nelson, Gary W. Beecham, Derek Michael Dykxhoorn, Karen Nuytemans, Liyong Wang, Olivia K. Gardner, Daniel A. Dorfsman, Eileen H. Bigio, Marsel M. Mesulam, Sandra Weıntraub, , Jeffery M. Vance

The paper finds that APOEϵ4 expression is higher in European ancestry carriers and linked to A1 reactive astrocytes, potentially explaining higher AD risk in this group.

Alzheimer s & Dementia · Dec 1, 2020Peer-reviewedGenomics

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into the complex genetic architecture

Ruth Chia, Marya S. Sabir, Sara Bandrés‐Ciga, Sara Sáez-Atiénzar, Regina Hertfelder Reynolds, Emil Karl Gustavsson, Ronald L. Walton, Sarah Ahmed, Coralie Viollet, Jinhui Ding, Mary B. Makarious, Mónica Díez-Fairén, Makayla K. Portley, Zalak Shah, Yevgeniya A. Abramzon, , Thomas G. Beach

This paper identifies five new genetic risk loci for Lewy body dementia through whole-genome sequencing and shows shared risk profiles with Alzheimer’s and Parkinson’s disease.

bioRxiv · Jul 6, 2020 · PreprintGenomics