Microglial SIRT2 deficiency aggravates cognitive decline and amyloid pathology in Alzheimer's disease
Noemí Sola-Sevilla, Maider Garmendia-Berges, Mikel Aleixo, MCarmen Mera-Delgado, Maite Solas, Rosa María Tordera, Lucía García‐Carracedo, Sara Expósito, Elena Anaya‐Cubero, Joaquín Fernández‐Irigoyen, Elisabeth Guruceaga, Enrique Santamaría, Eduardo Daniel Martín, Elena Puerta
This study shows that reducing SIRT2 in microglia worsens cognitive decline and amyloid pathology in Alzheimer's disease models.
Brain Behavior and Immunity · Jun 9, 2025Peer-reviewedNeuroscience