Joaquín Fernández‐Irigoyen

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α-synuclein preformed fibrils-induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

The paper uses proteomic analysis of the olfactory tract to identify pyroxamide, an HDAC1 inhibitor, as a potential therapeutic for Parkinson's disease by reducing α-synuclein fibril-induced toxicity in cell lines.

A generalizable normalization framework to decouple protocol and instrument effects: Application to high-sensitivity proteomics multicentric study (PME13)

This paper introduces a normalization framework to decouple protocol and instrument effects in multicenter proteomics studies, demonstrating its application to the PME13 dataset.

Multi-omics characterization of SIRT3 metabolism and its adaptation to the presence of amyloid-beta oligomers in nasal epithelial cells

The paper investigates the role of SIRT3 in nasal epithelial cell metabolism under amyloid-beta oligomer exposure using multi-omic approaches and identifies sex-dependent SIRT protein level differences in neurological disorders.

Phospho-signalling deregulation of the mTOR pathway in fibroblasts from LRRK2 Parkinson s patients

This study identifies mTOR pathway deregulation in fibroblasts from LRRK2 Parkinson's patients through proteomic and phospho-proteomic analysis.

Early, sex-dependent and progressive proteomic imbalance in the amygdala during Alzheimers disease progression

This study identifies sex-dependent and progressive proteomic changes in the amygdala across Alzheimer's disease stages, revealing potential sex-specific biomarkers and therapeutic targets.

Microglial SIRT2 deficiency aggravates cognitive decline and amyloid pathology in Alzheimer's disease

This study shows that reducing SIRT2 in microglia worsens cognitive decline and amyloid pathology in Alzheimer's disease models.

A double hit affecting the IKZF1-IKZF2 tandem in immune cells of schizophrenic patients regulate specific symptoms

The paper shows that reduced IKZF1 and IKZF2 in immune cells of schizophrenic patients leads to impaired neural circuits and schizophrenia-like symptoms in mice and human cell models.

Neuropathological stage-dependent proteome mapping of the olfactory tract in Alzheimer's disease: From early olfactory-related omics signatures to computational repurposing of drug candidates

This paper identifies stage-dependent proteomic changes in Alzheimer's disease olfactory tract and uses computational methods to repurpose drugs that can reverse early AD-related omics signatures.

4R-Tau seeding activity unravels molecular subtypes in patients with Progressive Supranuclear Palsy

The paper investigates molecular subtypes in PSP by analyzing tau seeding activity and identifies immune-related pathways associated with disease progression.

GLUT1 ablation in astrocytes paradoxically improves central and peripheral glucose metabolism via enhanced insulin-stimulated ATP release

This study shows that removing GLUT1 in astrocytes improves brain and peripheral glucose metabolism without affecting cognition, due to increased insulin-stimulated ATP release.

Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions

The paper investigates how SARS-CoV-2 structural proteins affect metabolic and immunological processes in mouse olfactory bulb cells, identifying TGF-beta signaling as a key activation node.