Defining the Mycobacterium tuberculosis Pangenome and Suggestions for a New Composite Reference Sequence
Poonam Chitale, Elissa Ocke, Aubrey R. Odom-Mabey, Howard Fan, Alexander Henoch, Karla A. Vasco, Emily C. Fogarty, Courtney A. Grady, Alexander D. Lemenze, Pradeep John Kumar, Shannon D. Manning, A. Murat Eren, William Evan Johnson, David Alland
This study generates 50 complete Mtb genomes, identifies core and accessory gene clusters, and proposes a new pangenome reference resource to improve TB research.
bioRxiv · Nov 3, 2025 · PreprintMicrobiology