Label-free 3D virtual histology of human formalin-fixed paraffin-embedded (FFPE) prostate needle biopsies with propagation-based phase-contrast micro-CT (PBCT)
Andrew L. Sugarman, Daniel J. Vanselow, Guoli Chen, Elizabeth Clark, Dilworth Y. Parkinson, Patrick J. La Rivière, Justin Silverman, Joshua Warrick, Keith C. Cheng
This paper introduces a method using PBCT to create 3D virtual histology of FFPE prostate biopsies, enabling nondestructive 3D analysis of tumor architecture and distinguishing Gleason patterns.
bioRxiv · Jun 7, 2026 · PreprintPathology