Keith C. Cheng

This paper introduces a method using PBCT to create 3D virtual histology of FFPE prostate biopsies, enabling nondestructive 3D analysis of tumor architecture and distinguishing Gleason patterns.

The paper uses high-resolution microCT to create a 3D digital octopus, revealing neural pathways and organ structures from periphery to brain.

The paper characterizes the structural and neuronal organization of venom glands in cephalopods and identifies molecular mechanisms regulating venom release.

This study identifies a link between ARM-type fold domain loss in zebrafish Armc9, inflammation, and spinal curvature, suggesting a role in ciliary signaling and adolescent idiopathic scoliosis.

The paper develops a 3D developmental common coordinate framework (DevCCF) for mouse brains across multiple developmental stages to enable data integration and analysis of brain development.

The paper investigates genetic contributions to skin color variation in a Caribbean population with Native American, African, and European ancestry, identifying specific alleles and ancestry effects on pigmentation.

The paper develops a semi-automated method to segment and model blood cells in zebrafish larvae using X-ray histotomography, enabling quantitative geometric analysis across developmental stages and mutants.

This study maps the whole-brain connectivity of oxytocin neurons in mice, revealing distinct roles of paraventricular and supraoptic OT neurons in circuit-specific functions.

This paper introduces a micro-CT detector with 0.5 µm pixel size and 6 mm field-of-view, achieving 1.182 µm spatial resolution for 3D imaging of micron-scale structures in biological and non-biological samples.

The paper maps the spatial relationship between cerebrovasculature, pericytes, and neuronal cell types in mice to reveal how they support regional brain energy homeostasis.

This study shows that a zebrafish DNA polymerase mutation leads to DNA damage, S phase arrest, and cell death over time, with effects varying by cell type and replication rate.

The paper merges two mouse brain atlases to create a unified anatomical labeling system with improved consistency and visualization tools.