The circadian regulator PER1 inhibits osteoclastogenesis by activating inflammatory genes
Nobuko Katoku-Kikyo, Elizabeth K. Vu, Samuel Mitchell, Ismael Y. Karkache, Elizabeth W. Bradley, Nobuaki Kikyo
This study shows that PER1 inhibits osteoclastogenesis by upregulating inflammatory genes, linking circadian rhythms to bone remodeling and suggesting therapeutic targets for inflammatory bone diseases.
Journal of Bone and Mineral Research · Feb 4, 2026Peer-reviewedDevelopmental Biology