Ismael Y. Karkache

This study shows that PER1 inhibits osteoclastogenesis by upregulating inflammatory genes, linking circadian rhythms to bone remodeling and suggesting therapeutic targets for inflammatory bone diseases.

This study shows that PER1 and PER2 regulate osteoclastogenesis by balancing innate immunity gene activities, with distinct effects in single and double knockouts.

This study identifies CD11B+CD36+ macrophages as bone anabolic cells that limit age-related cortical bone loss in mice and humans.