Discovery of a Novel Non-MET-Mediated Otoprotective Compound Against Aminoglycoside-Induced Ototoxicity
Elizabeth Kara, Christopher Nicolet, Shaikh Emdadur Rahman, Travis Hudok, Caleb Leach, Kaden Falkner, Ken Cornell, Dong Xu
This paper identifies a novel otoprotective compound, 28510, that prevents aminoglycoside-induced hearing loss without inhibiting MET channels, showing broad efficacy and favorable drug properties.
bioRxiv · May 18, 2026 · PreprintPharmacology & Toxicology