Rare extreme polygenic risk scores strongly indicate Alzheimer's disease risk
Elizabeth L. Ward, Peter T. Nelson, Yuriko Katsumata, David W. Fardo, Gregory A. Jicha, Alzheimer's Disease Neuroimaging Initiative, Justin B. Miller
The paper identifies individuals with extreme polygenic risk scores (PRS) for Alzheimer's disease (AD) and shows they have significantly elevated AD risk across multiple ancestries and APOE diplotypes.
medRxiv · Sep 9, 2026 · PreprintGenetic & Genomic Medicine