The paper identifies individuals with extreme polygenic risk scores (PRS) for Alzheimer's disease (AD) and shows they have significantly elevated AD risk across multiple ancestries and APOE diplotypes.

medRxiv · Sep 9, 2026 · PreprintGenetic & Genomic Medicine

Alzheimer's Polygenic Risk Scores Are Not Interchangeable: Evidence from 1,752 Models

Elizabeth L. Ward, Peter T. Nelson, Yuriko Katsumata, David W. Fardo, Gregory A. Jicha, Alzheimer's Disease Neuroimaging Initiative, Justin B. Miller

The paper evaluates 1,752 polygenic risk score models for Alzheimer's disease and finds significant variability in results across methods and ancestries.

medRxiv · Sep 7, 2026 · PreprintGenetic & Genomic Medicine

Differential Speed and Accuracy Trade-off in Working Memory Retrieval and Bilateral Precuneus between Older Men and Women

Darlingtina Kenechi Esiaka, Stephanie Strothkamp, Banafsheh Aghayeeabianeh, Lucas S. Broster, David K. Powell, Gregory A. Jicha, Yang Jiang

This study finds sex differences in the relationship between precuneus volume and working memory performance, with women showing stronger correlations between left precuneus volume and memory accuracy.

Brain and Behavior · Sep 1, 2025Peer-reviewedNeuroscience

Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort

Edric D. Winford, Jenny Lutshumba, Barbara J. Martin, Donna M. Wilcock, Gregory A. Jicha, Barbara S. Nikolajczyk, Ann Marie Stowe, Adam D. Bachstetter

This study examines the association between terminally differentiated effector memory T cells (TEMRAs) and cognitive and AD-related biomarkers in an aging cohort, finding CD8+ TEMRAs correlate with neuroinflammation markers.

Immunity & Ageing · Jun 12, 2024Peer-reviewedNeuroscience

Polygenic effects on the risk of Alzheimer's disease in the Japanese population

Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, the Alzheimer’s Disease Neuroimaging Initiative, , Gary R. Conrad

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

Alzheimer s Research & Therapy · Feb 27, 2024Peer-reviewedGenetic & Genomic Medicine

A blood-based signature of cerebral spinal fluid Aβ1-42 status

Benjamin Goudey, Bowen John Fung, Christine Schieber, Noel Garry Faux, Michael Walter Weiner, Paul S. S. Aisen, Ronald Carl Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel A. Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, , Kyle B. Womack

This paper develops a blood-based machine learning model to predict cerebral spinal fluid Aβ1-42 levels, showing high accuracy in identifying Alzheimer's disease risk.

Scientific Reports · Mar 10, 2019Peer-reviewedNeuroscience

Analysis of shared heritability in common disorders of the brain

Verneri Anttila, Brendan K Bulik-Sullivan, Hilary K. Finucane, Raymond Kenney Walters, José Brás, Laramie E. Duncan, Valentina Escott‐Price, Guido J. Falcone, Padhraig Gormley, Rainer Malik, Nikolaos A. Patsopoulos, Stephan Ripke, Zhi Wei, Dongmei Yu, Phil Hyoun Lee, , Nicholas A. Furlotte

Genetic correlations across 25 brain disorders (215,683 cases) reveal broad psychiatric common-variant sharing, largely distinct neurological disorders, and migraine as the only significant cross-category link.

Science · Jun 21, 2018Peer-reviewedGenetics✦ In-depth digest