Peter T. Nelson

This study shows human circTau 12->7 RNA is translated in mouse neurons and causes tau aggregation, suggesting it may contribute to Alzheimer's disease.

This study identifies cell-type-specific histone acetylation changes in Alzheimer's disease, highlighting MITF's potential role in microglial dysfunction.

The paper identifies age-associated B cells (ABCs) in the CNS that develop from a localized progenitor pool and contribute to impaired post-stroke recovery in mice.

The paper identifies individuals with extreme polygenic risk scores (PRS) for Alzheimer's disease (AD) and shows they have significantly elevated AD risk across multiple ancestries and APOE diplotypes.

The paper evaluates 1,752 polygenic risk score models for Alzheimer's disease and finds significant variability in results across methods and ancestries.

This paper develops a deep learning framework to segment and quantify cerebral amyloid angiopathy in whole-slide histopathology images, achieving high accuracy and robust generalization across cohorts.

The paper identifies citrullination of tau as a novel posttranslational modification in Alzheimer's disease and tauopathy models, showing its association with disease progression.

This study investigates calcium dynamics in reactive astrocytes and their coupling with cerebral arterioles in an Alzheimer's disease mouse model, finding impaired signaling fidelity between astrocyte endfeet and arterioles.

This study identifies molecular subtypes based on cryptic exon burden in hippocampal tissue, revealing proteomic changes linked to TDP-43 pathology in LATE and Alzheimer's disease.

This study uses spatial transcriptomics to show that proximity to amyloid plaques in AD models alters microglial metabolism, revealing conserved patterns in human tissue.

The paper shows that loss of age-related m6A RNA methylation in Alzheimer's disease brains is linked to GABAergic dysfunction and synaptic issues.

This study identifies TDP-43-driven splicing dysregulation as a common mechanism in ALS, FTD, and Alzheimer's disease, linking them through mis-spliced mRNAs like APP.

This study identifies citrullination as a novel irreversible post-translational modification of TDP-43 linked to structural changes, aggregation, and pathology in TDP-43 proteinopathies.

This study identifies differentially expressed genes and pathways in Alzheimer's disease brain tissue from African American donors, highlighting potential targets for treatment.

The paper uses long-read RNAseq to identify new RNA isoforms in Alzheimer's disease brain tissue and demonstrates their medical relevance.

The paper develops a high-throughput single-cell genomics approach to study age-related and Alzheimer's disease-associated cell population dynamics and molecular signatures in human and mouse brains.

This paper introduces TrackerSci, a technique to profile progenitor cells in mouse and human brains, revealing cell-type-specific dynamics and aging-related changes.

This study evaluates blood-based exosomal TDP-43 as a biomarker for LATE-NC, finding elevated levels in ADEs from LATE-NC subjects but no correlation with cognition or APOE status.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

This study investigates the relationship between age and dystrophic microglia in the human brain, finding that dystrophic microglia are more prevalent in neurodegenerative diseases than in healthy aging.