A recently evolved TAF8 isoform arising from an Alu insertion increases TFIID assembly complexity in the human lineage
Andrea Bernardini, Alberto Gallo, Elizabeth Scheer, Bastien Morlet, Diletta Dolfini, Roberto Mantovani, Stéphane D. Vincent, Làszlò Tora
The paper identifies a human-specific TAF8 isoform arising from an Alu insertion that alters TFIID complex composition and function.
bioRxiv · Jan 19, 2026 · PreprintMolecular Biology