Làszlò Tora

This study shows that TBPL2-dependent transcription is essential for maintaining cellular organization in growing oocytes by regulating RNA stability and decay machinery.

The paper identifies a human-specific TAF8 isoform arising from an Alu insertion that alters TFIID complex composition and function.

The paper investigates the dynamic behavior of RNA polymerase II and its initiation factors during transcription activation in live cells, revealing distinct kinetic behaviors and a quantitative model for PIC assembly.

This study reports the high-resolution structure of the human SAGA complex, revealing how the SPL module and TAF6L/HEAT repeats are integrated into the complex and their functional implications.

The paper shows that TIP60 depletion alters transcription and is offset by changes in RNA export and stability, revealing gene-specific transcript buffering mechanisms.

This study shows that partially assembled TFIID complexes can initiate RNA polymerase II transcription but cannot fully replace holo-TFIID over time.

This study shows that ATAC and SAGA HAT modules enhance transcription factor binding to nucleosomes without requiring histone acetylation.

This study shows that ATAC and SAGA coactivator complexes assemble co-translationally in the cytoplasm, but their localization and functions differ.

The paper shows TFIID biogenesis occurs co-translationally through hierarchical assembly driven by TAF1.

This study shows that SUPT3H is not essential for SAGA complex assembly or overall Pol II transcription but is required for mESC growth and self-renewal.

The study identifies specific TAF8 regions critical for TFIID lobe B assembly and TAF2 interactions, showing their necessity for mouse embryonic stem cell survival.

This study shows that USP22 and ATXN7L3 are essential for mouse development, with distinct roles, and that H2Bub1 deubiquitylation does not globally regulate RNA polymerase II transcription.

The paper improves the ChEC-seq method to more accurately map transcription coactivators and transcription factors' genome-wide DNA binding sites.

The paper shows that the TBPL2/TFIIA complex establishes the oocyte transcriptome by using a specific TSS recognition code through oocyte-specific promoter usage.

The paper identifies global regulatory transitions at core promoters during mammalian germline development, showing a shift from somatic to maternal promoter codes in oogenesis.

This study shows the INO80 complex helps RNA Polymerase II move past stalled positions, aiding non-coding RNA termination in yeast.

The paper shows that mammalian nuclear transcription complexes assemble co-translationally, with dimerization domains dictating the assembly pathway.

The paper identifies a nuclear transcription compartment that enables early gene expression before genome activation in metazoan embryos.

This study shows that TAF10 is not essential for early somitogenesis but is critical for lateral plate differentiation in the mouse embryo.