NeurosciencebioRxivPreprint
Excitatory neurons downregulate synaptic proteins before motor onset and glia reduce neuronal support in Huntington disease mice
Rodrigo Alvarez Pardo, Sicheng Luo, Patricia Rodriguez…·Beatriz Alvarez-Castelao
This study identifies cell-type-specific proteomic changes in Huntington's disease mice, showing early synaptic protein downregulation in neurons and reduced neuronal support in glia as disease progresses.
DOI 10.64898/2026.11.12.766120