Marko Jovanović

This study identifies Gim3 as a critical regulator of meiotic chromosome segregation in budding yeast, revealing its role in spindle sensitivity to tubulin levels and meiotic cellular remodeling.

The paper shows how two reverse transcriptases with different templating strategies work together to produce complementary DNA for antiviral defense.

The paper shows that the endogenous UPR in budding yeast is essential for gametogenesis, coordinating translation and ER structure through a distinct mechanism from exogenous UPR activation.

This paper identifies PTP1B substrates using in situ photo-crosslinking, revealing new substrates and interactions, including EGF receptor binding.

The paper uses integrated imaging and omics approaches to show that Actb and Arc mRNAs are packaged into distinct granules with different trafficking dynamics and functional roles.

This study identifies Blm10 as a proteasome-associated protein that modulates proteasome activity and maintains proteostasis and gamete quality in yeast.

This study identifies eIF4G2 as a translational checkpoint that restricts pancreatic cancer progression by maintaining epithelial identity and limiting metastasis.

This study shows that HP1β regulates olfactory receptor choice and neuronal identity in mice by modulating H3K9me3 levels and chromatin structure, leading to changes in OR expression patterns and reduced receptor diversity.

The paper identifies a neuron type-specific microexon in Ank3/ankyrin-G that modulates calcium activity and neuronal excitability through alternative splicing.

This study shows that Mex3a regulates neuronal differentiation by controlling translation and trafficking of cell surface proteins, cilia structure, and planar cell polarity in olfactory sensory neurons.

This study uses proximity-labeling proteomics to analyze how SHP2 mutations alter its interactome and localization, revealing functional consequences of different mutation types.

The paper identifies that ~12% of human intergenic enhancer RNAs contain long open reading frames that can be translated into proteins.

SPRINT-MS identifies protein-protein interactions using pooled IP-MS and sparse signal recovery, achieving high throughput and efficiency comparable to individual IP-MS experiments.

The paper identifies DRT10, an antiviral reverse transcriptase, and shows its structural and mechanistic similarities to telomerase, suggesting a bacterial origin for telomerase.

This paper introduces RAPPL, a rapid, simple, and cost-effective method for isolating ribosomes and translational machinery, demonstrating its utility in functional and structural studies across various species and sample types.

SPIDR is a high-throughput method for mapping RNA-protein interactions that identifies 4EBP1's role in selectively repressing mRNA translation under mTOR inhibition.

The paper reveals a novel DNA homopolymer synthesis mechanism by DRT9, triggered by viral infection to induce abortive infection and population-level immunity.

This study identifies eIF2A's role in ribosome-associated quality control by showing it antagonizes USP10-dependent 40S subunit rescue, affecting turnover under stress.

This paper shows that Grb2 binding to PTP1B allosterically enhances its catalytic activity through structural changes, revealing a new regulatory mechanism for PTP1B in cell signaling.

The paper constructs an RNA-aware RBP-centric PPI map across the mRNA life-cycle, revealing 20,359 novel interactions and showing 73% are RNA-dependent.

The paper demonstrates that bacterial reverse transcriptases synthesize extrachromosomal genes via rolling-circle amplification to confer antiviral immunity.

This study shows Dbp1 is a less effective paralog of Ded1 in yeast, supporting impaired translation and lacking heat stress response, used in nutrient-deficient conditions.

The paper investigates how different PUM1 mutations lead to distinct phenotypes by analyzing PUM1 interactomes and showing that dosage sensitivity involves non-linear mechanisms.

The paper uses a machine learning-based high-throughput approach to analyze charge state distributions of peptides, revealing two distinct charging regimes with different sequence determinants.

The paper introduces SEC-MX, a method to simultaneously study protein assembly-states and phosphorylation events, and demonstrates its application in HEK293 and HCT116 cells.

The paper shows that deleting DBP1 in yeast using a selection cassette causes off-target repression of MRP51 through a LUTI-based mechanism, leading to mutant phenotypes.

This study characterizes epigenetic aging in human classical monocytes, identifying age-associated DNA methylation changes and their links to gene expression and disease associations.

This study shows that Aurora B-dependent phosphorylation of Ndc80 promotes its degradation during meiosis, regulating kinetochore composition and preventing chromosome mis-segregation.

The paper introduces SPRITE, a method for detecting higher-order DNA interactions, and shows that nuclear bodies act as inter-chromosomal hubs shaping 3D genome organization.