Modeling the metabolic heterogeneity of high-grade serous ovarian cancer solid tumors in 3D Microphysiological systems
Paula M. Mañán-Mejías, Nicha Boonpattrawong, Michael Bérubé, Ellinore K Letts, Finnbar L. K. Reed-McBain, Ana Sofia Peraza Munuzuri, Yalmarie Numan Vazquez, Manish S. Patankar, Marı́a Virumbrales-Muñoz
This paper develops a 3D microphysiological system to model metabolic heterogeneity in HGSOC spheroids and tests the effect of atovaquone on tumor progression and metabolism.
bioRxiv · Jul 1, 2026 · PreprintCancer Biology