Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
Charlotte M. Zammit, Cory M. Nadel, Ying Q. Lin, Sajjan Koirala, Elnaz Ahani, Patrick Ryan Potts, Daniel K. Nomura
This paper identifies a covalent compound EN1441 that selectively degrades AR and AR-V7 in androgen-independent prostate cancer cells by targeting an intrinsically disordered cysteine.
Journal of the American Chemical Society · Jun 9, 2025Peer-reviewedCancer Biology