Coordinated regulation of Mdr1- and Cdr1-mediated protection from antifungals by the Mrr1 transcription factor in emerging Candida spp.
Dhanabala-Subhiksha Rajesh-Khanna, Carolina G. Piña Páez, Susu He, Elora G. Dolan, Kiran S. Mirpuri, Jason Stajich, Deborah A. Hogan
This study identifies Mrr1 as a transcription factor coordinating MDR1 and CDR1 expression in Candida lusitaniae, contributing to antifungal resistance through efflux pumps and stress response genes.
mBio · Oct 7, 2025Peer-reviewedMicrobiology