In situ vaccine effect of radiotherapy is associated with intratumoural ERV reactivation and RNA virus sensing
Stella Logotheti, Elif Yildiz, Sarah Hasan, Elpida Theodoridou, Stefan Kuhn, Thorsten Stiewe, Stephan Marquardt, Athanasia Pavlopoulou, Joao Seco
This study identifies that radiotherapy-induced antitumor immunity involves ERV reactivation and RNA virus sensing, with SFRT showing stronger immune responses than conventional RT.
bioRxiv · Feb 9, 2026 · PreprintCancer Biology