Thorsten Stiewe

This study identifies that radiotherapy-induced antitumor immunity involves ERV reactivation and RNA virus sensing, with SFRT showing stronger immune responses than conventional RT.

The paper identifies hangover's role in regulating gene expression by inhibiting NSL-mediated H4K16 acetylation at transcriptional start sites in Drosophila.

This study identifies synergistic metabolic inhibitors that selectively target ovarian and colorectal cancer cells by disrupting both glycolysis and oxidative phosphorylation.

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

This study identifies SAMD1 as a repressor of EMT-related genes in PDAC, showing that its loss increases migration and that FBXO11 ubiquitinates SAMD1 to inhibit its function.

This study shows IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent excessive inflammation in AML cells, revealing a potential therapeutic target.

This study identifies HMG20A as a key regulator of head and heart development by modulating transcription programs in neural crest cells and cardiomyocytes through its association with the H2A.Z/PWWP2A/NuRD complex.

The paper shows RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling by competing with nucleosome substrates, suggesting an evolutionary conserved mechanism.

This study identifies Ush's role in regulating gene expression, metabolism, and cell cycle in Drosophila hematopoiesis through its interaction with the NuRD complex.

This study establishes MDM2 inhibitor-resistant AML sub-lines and finds that resistance arises from pre-existing TP53 mutations or de novo mutations, with variable drug sensitivity despite loss of p53 function.