Vertical inhibition of the autophagy pathway impairs growth and enhances sensitivity to mTORC1 inhibition in pancreatic ductal adenocarcinoma
Mallory K. Roach, Seamus E. Degan, Jonathan M. DeLiberty, Lily M. Pita, Noah L. Pieper, 杨闰英, Khalilah E. Taylor, Elyse G. Schechter, Ryan N. Robb, Mariaelena Pierobon, Clint A. Stalnecker, Emanuel F Petricoin, Kirsten L. Bryant
This study identifies that vertical inhibition of the autophagy pathway enhances sensitivity to mTORC1 inhibition in PDAC, improving therapeutic efficacy.
bioRxiv · Jun 29, 2026 · PreprintCancer Biology