Cardiac Calsequestrin is a Physiological Dimer that Polymerizes through a Ca2+-Triggered Cooperative Switch
Chiara Marabelli, Demetrio Julián Santiago, Emanuele Pirana, Chiara Di Antonio, Anselmo Canciani, Martino Bolognesi, Federico Forneris, Silvia Giuliana Priori
This study shows cardiac Calsequestrin (CASQ2) is an intrinsic dimer that polymerizes via a Ca2+-triggered cooperative switch, with K+ ions modulating this process.
bioRxiv · Apr 7, 2026 · PreprintBiochemistry