Structure of the SMYD2-PARP1 Complex Reveals Both Productive and Allosteric Modes of Peptide Binding
Yingxue Zhang, Eid S. Alshammari, Jacob Sobota, Nicolas Spellmon, Emerson Perry, Tianxin Cao, Thamarahansi Mugunamalwaththa, Sheila Kathleen Smith, J.S. Brunzelle, Gensheng Wu, Timothy L. Stemmler, Jianping Jin, Chunying Li, Zhe Yang
The paper presents crystal structures of SMYD2, revealing an allosteric binding site that binds peptides, proteins, and small molecules, influencing catalytic activity and substrate specificity.
bioRxiv · Dec 3, 2024 · PreprintBiochemistry