This study identifies enhanced phenolic chemical defense as a key mechanism for resistance to multiple soybean cyst nematode populations in wild soybean.

bioRxiv · Sep 17, 2026 · PreprintPlant Biology

SUV39H1 Preserves Cancer Stem Cell Chromatin State and Properties in Glioblastoma

Chunying Li, Qiqi Xie, Sugata Ghosh, Bihui Cao, Yuanning Du, Vo Van Giau, Timothy Y. Huang, Charles Spruck, Richard L. Carpenter, Yanru Wang, Qing Richard Lu, Kenneth P. Nephew, Jia Shen

This paper shows SUV39H1 is critical for maintaining glioblastoma stem cell properties and progression, and targeting it enhances chemotherapy effectiveness.

JCI Insight · Mar 9, 2025Peer-reviewedCancer Biology

Structure of the SMYD2-PARP1 Complex Reveals Both Productive and Allosteric Modes of Peptide Binding

Yingxue Zhang, Eid S. Alshammari, Jacob Sobota, Nicolas Spellmon, Emerson Perry, Tianxin Cao, Thamarahansi Mugunamalwaththa, Sheila Kathleen Smith, J.S. Brunzelle, Gensheng Wu, Timothy L. Stemmler, Jianping Jin, Chunying Li, Zhe Yang

The paper presents crystal structures of SMYD2, revealing an allosteric binding site that binds peptides, proteins, and small molecules, influencing catalytic activity and substrate specificity.

bioRxiv · Dec 3, 2024 · PreprintBiochemistry

Dimethylarsenic acid (DMA) accumulation positively correlates with realgar-induced subchronic toxicity in rats

Yan Yi, Shuangrong Gao, Jing Xia, Yong Zhao, Chunying Li, Yushi Zhang, Lianmei Wang, Chen Pan, Suyan Liu, Jiayin Han, Aihua Liang, Ji Shen

This study shows that dimethylarsenic acid (DMA) accumulation correlates with realgar-induced toxicity in rats, with liver and kidney damage reversing after drug withdrawal.

bioRxiv · Aug 22, 2018 · PreprintPharmacology & Toxicology